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BMS Active Not Yet Recruiting Study icon

Active, Not Recruiting

Trial ID IM034-001  |   NCT04736134

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986326 in Healthy Participants

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Sorry, this study is no longer accepting new participants, but is still ongoing.
You may click the “Check Your Eligibility” button and answer a few questions about your health to find out if you might be a match to another study.

Summary

  • Phase 1
  • Male and Female Gender icon
  • 18-50
    Age Range
  • BMS Active Not Yet Recruiting Study icon
    Active, Not Recruiting

Overview

The purpose of this study is to evaluate the safety, tolerability, drug levels, drug effects, and immunogenicity of BMS-986326 after infusion or injection in healthy participants. The results of this study will guide the selection of the dose range, dosing frequency, and the route of administration for future studies of BMS-986326 in participants with immune-mediated diseases.

Key Eligibility Criteria

Inclusion Criteria: - In good health, as determined by the investigator based on a physical examination at screening - Body mass index (BMI) ≥ 18 and ≤ 30 kg/m^2 at screening - Afebrile, with supine systolic blood pressure (BP) ≥ 90 and ≤ 140 mmHg and supine diastolic BP ≥ 50 and ≤ 90 mmHg and heart rate ≥ 50 and ≤ 90 bpm at screening - Male participants are eligible to participate in cohorts (A1-B3).Women not of child bearing potential (WNOCBP) are eligible to participate in all cohorts (A1-B3 and C1-C2) Women of child-bearing potential (WOCBP) are only eligible for the subcutaneous (SC) cohorts (B1-B3 and C1-C2) - Must agree to follow specific methods of contraception, if applicable Exclusion Criteria: - Women who are pregnant or lactating - History of, or active, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection - Evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, echocardiogram (ECG), or clinical laboratory determinations beyond what is consistent with healthy participants - History of serious adverse reaction or hypersensitivity to any (subcutaneous) SC- or (intravenous) IV-administered biological therapeutic, including IV immunoglobulins and human blood products Other protocol-defined inclusion/exclusion criteria apply

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Active Treatment (BMS 986326) IV

ASSIGNED INTERVENTION
  • Biological: BMS-986326

Study Arms

Experimental: Active Treatment (BMS 986326) SC

ASSIGNED INTERVENTION
  • Biological: BMS-986326

Study Arms

Placebo Comparator: Multiple Ascending Dose Placebo SC

ASSIGNED INTERVENTION
  • Other: Multiple Ascending Dose Placebo

Study Arms

Experimental: Multiple Ascending Dose SC

ASSIGNED INTERVENTION
  • Biological: Multiple Ascending Dose SC

Study Arms

Placebo Comparator: Placebo IV

ASSIGNED INTERVENTION
  • Other: Placebo matching BMS-986326

Study Arms

Placebo Comparator: Placebo SC

ASSIGNED INTERVENTION
  • Other: Placebo matching BMS-986326