Inclusion Criteria:
Healthy Participants (Part A and Part B)
- Healthy male and female participants as determined by no clinically significant
deviation from normal in medical history, physical examination (PE),
electrocardiograms (ECGs), and clinical laboratory determinations
- Males and Females, ages 18, or local age of majority, to 50 years, inclusive at
screening
- Body mass index (BMI):18.0 to 30.0 kg/m2, weight: ≥ 50 kg at screening
- Must be fully vaccinated against SARS-CoV-2
Participants with Sjögren's Syndrome (Part C)
- Sjögren's syndrome in the absence of another immune-mediated disease or rheumatologic
condition based on the 2016 American College of Rheumatology-European League Against
Rheumatism (EULAR) Classification Criteria for primary Sjögren's syndrome (pSS).
Historical diagnosis as pSS documented in medical records, using the 2016 ACR/EULAR
criteria, is also acceptable
- Seropositive for anti-Sjögren's syndrome antigen A antibody (anti-SSA). Previous
anti-SSA are also acceptable, and results should be documented in the Case Report Form
(CRF) as past medical history
- Males and females, ages 18, or local age of majority, to 75 years, inclusive at
screening
- Body mass index (BMI): 18.0 to 35.0 kg/m2; weight ≥ 50 kg at screening
- Must be fully vaccinated against SARS-CoV-2 according to local regulations
Exclusion Criteria:
Healthy Participants (Part A and Part B) - Any significant acute or chronic medical illness
Healthy Participants (Part A and Part B) and Participants with Primary Sjögren's Syndrome
(pSS) (Part C)
- Any major surgery within 4 weeks prior to study drug administration, or any surgery
planned during the course of the study
Other protocol-defined inclusion/exclusion criteria apply
Recruiting
