Active, Not Recruiting
A Study of BMS-986249 Alone and in Combination With Nivolumab in Advanced Solid Tumors - CA030-001
Updated: 1 February, 2023 | ClinicalTrials.gov
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Trial Details
Phase
Gender(s)
Age Range
Active, Not Recruiting
Treatment Options
Inclusion Criteria: - Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic, recurrent, and/or unresectable) with measurable disease or metastatic disease documented by either bone lesions on radionuclide bone scan and/or soft tissue lesions on CT/MRI for prostate cancer and have at least 1 lesion accessible for biopsy. For Part 2B participants with HCC, intermediate disease is allowed. - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Must have received, and then progressed, relapsed, or been intolerant to, at least 1 standard treatment regimen in the advanced or metastatic setting according to tumor type, if such a therapy exists - Prior anti-cancer treatments such as chemotherapy, radiotherapy, or hormonal are permitted for some participants - Willing and able to comply with all study procedures Exclusion Criteria: - Primary central nervous system (CNS) malignancies, tumors with CNS metastases as the only site of disease or active brain metastases will be excluded - Other active malignancy requiring concurrent intervention - Prior organ allograft - Active, known, or suspected autoimmune disease Other protocol-defined inclusion/exclusion criteria apply
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