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Recruiting

Safety Study of Anti-LAG-3 in Relapsed or Refractory Hematologic Malignancies - CA224-022

Updated: 31 July, 2018   |   ClinicalTrials.gov

CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the trial guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 10

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: BMS-986016
Biological: BMS-986016
Experimental: BMS-986016 + BMS-936558
Biological: BMS-936558 Biological: BMS-986016

Key Eligibility Criteria

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - For dose escalation monotherapy: CLL, HL, NHL, MM - For dose expansion monotherapy: CLL, HL, NHL - For dose escalation and dose expansion in combination with BMS-936558: HL and DLBCL - Progressed, or been intolerant to, at least one standard treatment regimen - Not eligible for or declined transplantation or any standard therapy known to be life prolonging or life saving - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 - At least 1 lesion with measurable disease at baseline - Availability of an existing tumor biopsy sample (or consent to allow pre-treatment tumor biopsy if sample not available) Exclusion Criteria: - Known or suspected central nervous system (CNS) metastases or with the CNS as the only site of active disease (controlled CNS metastases are allowed) - Autoimmune disease - Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent - Uncontrolled or significant cardiovascular disease Other protocol defined inclusion/exclusion criteria could apply

Have questions? Call 855-907-3286 or Email Us

Have questions?
Call 855-907-3286 or Email Us