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Trial ID CV029-1001  |   NCT06122779

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Summary

  • Phase 2
  • Male and Female Gender icon
  • 40-90
    Age Range
  • 37
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

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Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
  • Adult participants with stable, symptomatic HFpEF with a normal heart pumping ability.

    Exclusion Criteria

    Exclusion Criteria Icon
    • Participants must not have a known diagnosis of obstructive or genetic hypertrophic cardiomyopathy or infiltrative/storage disorder such as cardiac amyloidosis, or any other acute or serious condition that could interfere with assessments during the study or may pose a risk to the participant.
      Additional Information *
      • Other protocol-defined Inclusion/Exclusion criteria apply.

        Treatment Options

        Study Arms

        ASSIGNED INTERVENTION

        Study Arms

        Experimental: BMS-986435

        ASSIGNED INTERVENTION
        • Drug: BMS-986435

        Study Arms

        Placebo Comparator: Placebo

        ASSIGNED INTERVENTION
        • Other: Placebo
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