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  • NCT07291076

Not Yet Recruiting

A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206) - CA266-0006

Uppdaterad: 6 februari, 2026   |   ClinicalTrials.gov

Utskriftsvänlig sammanfattning

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Information om prövningen

  • Phase 1/Phase 2

    Fas

  • Kön

  • 18+

    Åldersintervall

  • 29

    Platser

  • Not Yet Recruiting

Behandlingsalternativ

Studiegrupper
TILLDELAD BEHANDLING
Experimental: Cohort 1A
Drug: Pumitamig, Ipilimumab
Experimental: Cohort 1B
Drug: Pumitamig, Ipilimumab
Experimental: Cohort 2A
Drug: Pumitamig, Ipilimumab
Experimental: Cohort 2B
Drug: Pumitamig, Ipilimumab
Other: Cohort 2C
Drug: Atezolizumab, Bevacizumab
Experimental: Cohort 2D
Drug: Pumitamig

Viktiga kriterier för deltagandet

Inclusion Criteria - Participants must have a histologically confirmed diagnosis of locally advanced or unresectable Hepatocellular Carcinoma (HCC). - Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. - Participants must have no prior systemic therapy for advanced/ unresectable HCC. - Participants must have measurable disease as per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Exclusion Criteria - Participants must not have significant bleeding or coagulation disorders or other obvious bleeding risk evidence. - Participants must not have an organ transplant or autoimmune disease. - Other protocol-defined Inclusion/Exclusion criteria apply.

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