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  • NCT07100080

Not Yet Recruiting

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01) - CA244-0010

Uppdaterad: 14 augusti, 2025   |   ClinicalTrials.gov

Utskriftsvänlig sammanfattning

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VÄLJ SPRÅK

Information om prövningen

  • Phase 2/Phase 3

    Fas

  • Kön

  • 18+

    Åldersintervall

  • 78

    Platser

  • Not Yet Recruiting

Behandlingsalternativ

Studiegrupper
TILLDELAD BEHANDLING
Experimental: Arm A
Drug: Iza-bren
Experimental: Arm B
Drug: Iza-bren
Active Comparator: Arm C
Drug: Carboplatin, Cisplatin, Pemetrexed
Experimental: Arm D
Drug: Iza-bren
Active Comparator: Arm E
Drug: Carboplatin, Cisplatin, Pemetrexed

Viktiga kriterier för deltagandet

Inclusion Criteria: - Non-squamous NSCLC, not amenable to treatment in curative intent. - Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation). - Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting. - Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed). Exclusion criteria: - Inadequate organ function and/or bone marrow reserve. - Leptomeningeal metastases or spinal cord compression. - Poorly controlled systemic medical conditions. - Other protocol-defined inclusion/exclusion criteria apply.

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