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Recruiting

A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors - CA233-0000

Uppdaterad: 28 oktober, 2024   |   ClinicalTrials.gov

Utskriftsvänlig sammanfattning

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Information om prövningen

  • Phase 1

    Fas

  • Kön

  • 18+

    Åldersintervall

  • 11

    Platser

  • Recruiting

Behandlingsalternativ

Studiegrupper
TILLDELAD BEHANDLING
Experimental: Part 1A: BMS-986484 Dose Escalation
Drug: BMS-986484
Experimental: Part 1B: BMS-986484 + Nivolumab Dose Escalation
Drug: BMS-986484 Biological: Nivolumab
Experimental: Part 2A: BMS-986484 Dose Expansion
Drug: BMS-986484
Experimental: Part 2B: BMS-986484 + Nivolumab Dose Expansion
Drug: BMS-986484 Biological: Nivolumab

Viktiga kriterier för deltagandet

Inclusion Criteria: - Locally advanced unresectable, metastatic, or recurrent malignant tumors including non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDAC), gastric/gastroesophageal junction adenocarcinoma (G/GEJC), microsatellite stable colorectal cancer (MSS CRC), and squamous cell carcinoma of the head and neck (SCCHN). - Must have measurable disease by response evaluation criteria in solid tumors version 1.1 (RECIST v1.1). - Must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1. Exclusion Criteria: - History of or with active interstitial lung disease or pulmonary fibrosis. - Active, known, or suspected autoimmune disease. - Serious uncontrolled medical disorders. - New onset, non-catheter-associated venous thromboembolism within the past 6 months. - Other protocol-defined Inclusion/Exclusion criteria apply.

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