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Szukaj Study Connect
  • NCT03994601

Active, Not Recruiting

An Investigational Immunotherapy Study of BMS-986288 Alone and in Combination With Nivolumab in Advanced Solid Cancers - CA043-001

Zaktualizowano: 17 kwiecień, 2024   |   ClinicalTrials.gov

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Szczegóły badania

  • Phase 1/Phase 2

    Etap

  • Płeć

  • 18+

    Zakres wieku

  • Active, Not Recruiting

Opcje leczenia

Grupy badania
PRZYPISANA INTERWENCJA
Experimental: Arm A BMS-986288
Drug: BMS-986288
Experimental: Arm B BMS-986288 in combination with Nivolumab
Drug: BMS-986288, Nivolumab
Experimental: Part 2C: BMS-986288 in combination with Nivolumab and Regorafenib
Drug: BMS-986288, Regorafenib, Nivolumab

Kluczowe kryteria kwalifikacyjne

For more information regarding Bristol Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Histologic or cytologic confirmation of select solid tumor that is advanced (metastatic, recurrent, and/or unresectable) with measurable disease and have at least 1 lesion accessible for biopsy - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Participants must have received, and then progressed, relapsed, or been intolerant to, at least 1 standard treatment regimen in the advanced or metastatic setting according to select solid tumor histologies Exclusion Criteria: - Participants with active, known or suspected autoimmune disease - Participants with other active malignancy requiring concurrent intervention - Participants with primary CNS malignancies or tumors with CNS metastasis as the only site of disease, will be excluded Other protocol defined inclusion/exclusion criteria could apply