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Szukaj Study Connect
  • NCT03785249

Recruiting

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 - CA239-0008

Zaktualizowano: 18 czerwiec, 2024   |   ClinicalTrials.gov

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Szczegóły badania

  • Phase 1/Phase 2

    Etap

  • Płeć

  • 18+

    Zakres wieku

  • 101

    Lokalizacje

  • Recruiting

Opcje leczenia

Grupy badania
PRZYPISANA INTERWENCJA
Experimental: Phase 1 Dose Exploration
Drug: MRTX849
Experimental: Phase 1b Expansion
Drug: MRTX849
Experimental: Phase 2
Drug: MRTX849
Experimental: Phase 2 Combination with Cetuximab
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Afatinib
Drug: Afatinib, MRTX849
Experimental: Pilot Phase 1b Combination with Cetuximab
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Cetuximab in NSCLC
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Cetuximab in PDAC
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Pembrolizumab
Drug: Pembrolizumab, MRTX849

Kluczowe kryteria kwalifikacyjne

Inclusion Criteria: - Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation - Unresectable or metastatic disease - Standard treatment is not available or patient declines; first-line treatment for NSCLC for certain cohorts - Adequate organ function Exclusion Criteria: - History of intestinal disease or major gastric surgery or inability to swallow oral medications - Other active cancer