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  • NCT06646276

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS). - CA245-0001

Oppdatert: 3 september, 2025   |   ClinicalTrials.gov

Utskriftsvennlig Sammendrag

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Vis detaljer

  • Phase 3

    Fase

  • Kjønn

  • 18+

    Aldersgruppe

  • 102

    Sted(er)

  • Recruiting

Behandlingsalternativer

Studiearmer
TILDELT INTERVENSJON
Experimental: Arm A
Biological: BMS-986489 (BMS-986012+Nivolumab) Drug: Carboplatin, Etoposide
Active Comparator: Arm B
Biological: Atezolizumab Drug: Carboplatin, Etoposide

Nøkkelkriterier for kvalifikasjon

Inclusion Criteria: - Participants must have diagnosis of Extensive-Stage Small Cell Lung Cancer (ES-SCLC). - Participants must be Healthy enough to do their normal activities with little or no help based on the ECOG performance scale. - Participants must have at least one tumor that can be measured using special imaging techniques like a CT scan or MRI at a site other than the brain and nervous system Exclusion Criteria: - Participants have already received certain types of treatment for extensive stage small cell lung cancer - Participants have certain health conditions, like spread of small cell lung cancer to the brain that are causing symptoms, certain lung diseases, heart diseases, infections, autoimmune diseases, other cancers, or a type of nerve damage called peripheral sensory neuropathy - Other protocol-defined Inclusion/Exclusion criteria apply.

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Bivirkninger (uønskede hendelser) og andre rapporterbare hendelser er definert her
For å rapportere bivirkninger (uønskede hendelser) eller reklamere på et legemiddel: Medisinsk informasjon

MLTNO2000046