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  • NCT05543629

Active, Not Recruiting

A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer - CA115-001

Oppdatert: 6 august, 2024   |   ClinicalTrials.gov

Utskriftsvennlig Sammendrag

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Vis detaljer

  • Phase 1/Phase 2

    Fase

  • Kjønn

  • 18+

    Aldersgruppe

  • Active, Not Recruiting

Behandlingsalternativer

Studiearmer
TILDELT INTERVENSJON
Experimental: Part A: BMS-986442 + Nivolumab
Biological: Nivolumab, BMS-986442
Experimental: Part B1: BMS-986442 + Nivolumab
Biological: Nivolumab, BMS-986442
Experimental: Part B2: BMS-986442 + Nivolumab
Biological: Nivolumab, BMS-986442
Experimental: Part C: BMS-986442 + Nivolumab + Docetaxel
Biological: BMS-986442, Nivolumab Drug: Docetaxel
Experimental: Part D: BMS-986442 + Nivolumab + Carboplatin + Pemetrexed
Biological: BMS-986442, Nivolumab Drug: Pemexetred, Carboplatin
Experimental: Part E: BMS-986442 + Nivolumab + Carboplatin + Paclitaxel
Biological: Nivolumab, BMS-986442 Drug: Paclitaxel, Carboplatin

Nøkkelkriterier for kvalifikasjon

Inclusion Criteria: - Participants in all parts of the study must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. - Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. - Participants must have a life expectancy of at least 3 months at the time of first dose. Exclusion Criteria: - Untreated symptomatic central nervous system metastases or leptomeningeal metastases. - Concurrent malignancy (present during screening) requiring treatment, or history of prior malignancy active within 2 years prior to randomization in study Part B1 or treatment assignment in all other study parts. - Participants with an active, known, or suspected autoimmune disease. Other protocol-defined inclusion/exclusion criteria apply.

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Bivirkninger (uønskede hendelser) og andre rapporterbare hendelser er definert her
For å rapportere bivirkninger (uønskede hendelser) eller reklamere på et legemiddel: Medisinsk informasjon

MLTNO2000046