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  • NCT05337137

Recruiting

A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer - CA224-106

Oppdatert: 7 mars, 2024   |   ClinicalTrials.gov

Utskriftsvennlig Sammendrag

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Skriv ut denne siden CA224-106
Last ned Veiledning for studiedeltakere

VELG SPRÅK

Vis detaljer

  • Phase 1/Phase 2

    Fase

  • Kjønn

  • 18+

    Aldersgruppe

  • 35

    Sted(er)

  • Recruiting

Behandlingsalternativer

Studiearmer
TILDELT INTERVENSJON
Experimental: Arm A: Relatlimab + Nivolumab + Bevacizumab
Drug: Relatlimab, Nivolumab, Bevacizumab
Experimental: Arm B: Placebo + Nivolumab + Bevacizumab
Drug: Nivolumab, Bevacizumab Other: Placebo

Nøkkelkriterier for kvalifikasjon

Inclusion Criteria: - Histologically confirmed advanced/metastatic hepatocellular carcinoma (HCC) - Naïve to systemic therapy for advanced/metastatic HCC (prior neo-adjuvant or adjuvant immunotherapy is permitted if recurrence occurs ≥ 6 months after treatment completion and the case is discussed with BMS medical team) - Child-Pugh score of 5 or 6 (ie, Child-Pugh A) - Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 Exclusion Criteria: - Known fibrolamellar HCC, sarcomatoid HCC or mixed cholangiocarcinoma and HCC - Prior allogenic stem cell or solid organ transplantation - Untreated symptomatic central nervous system (CNS) metastases - Clinically significant ascites as defined by: i) Prior ascites that required treatment and requires on-going prophylaxis, or ii) Current ascites requiring treatment Other protocol-defined inclusion/exclusion criteria apply

Vi anbefaler at du kontakter BMS for å rapportere bivirkninger.
Bivirkninger (uønskede hendelser) og andre rapporterbare hendelser er definert her
For å rapportere bivirkninger (uønskede hendelser) eller reklamere på et legemiddel: Medisinsk informasjon

MLTNO2000046