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Søk Study Connect

Active, Not Recruiting

An Investigational Immunotherapy Study of BMS-986249 Alone and in Combination With Nivolumab in Solid Cancers That Are Advanced or Have Spread - CA030-001

Oppdatert: 3 oktober, 2023   |   ClinicalTrials.gov

Utskriftsvennlig Sammendrag

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Vis detaljer

  • Phase 1/Phase 2

    Fase

  • Kjønn

  • 18+

    Aldersgruppe

  • Active, Not Recruiting

Behandlingsalternativer

Studiearmer
TILDELT INTERVENSJON
Experimental: Arm A
Biological: BMS-986249
Experimental: Arm B
Biological: BMS-986249, Nivolumab
Experimental: Part 2A Arm A
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm A: BMS-986249 + nivo then nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm B
Biological: Ipilimumab, Nivolumab
Experimental: Part 2A Arm B: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm C
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm D
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm E
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm E: Nivo
Biological: Nivolumab
Experimental: Part 2B Cohort 3: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249

Nøkkelkriterier for kvalifikasjon

For more information regarding Bristol Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic, recurrent, and/or unresectable) with measurable disease and have at least 1 lesion accessible for biopsy - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Participants must have received, and then progressed, relapsed, or been intolerant to, at least 1 standard treatment regimen in the advanced or metastatic setting according to solid tumor histologies Exclusion Criteria: - Participants with primary CNS malignancies or tumors with CNS metastases as the only site of disease, will be excluded - Prior anti-cancer treatments such as chemotherapy, radiotherapy, or hormonal are permitted - Participants with other active malignancy requiring concurrent intervention Other protocol defined inclusion/exclusion criteria could apply

Vi anbefaler at du kontakter BMS for å rapportere bivirkninger.
Bivirkninger (uønskede hendelser) og andre rapporterbare hendelser er definert her
For å rapportere bivirkninger (uønskede hendelser) eller reklamere på et legemiddel: Medisinsk informasjon

MLTNO2000046