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  • NCT02773030

Active, Not Recruiting

A Study to Determine Dose, Safety, Tolerability, Drug Levels, and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Participants With Multiple Myeloma - CC-220-MM-001

Updated: 21 June, 2024   |   ClinicalTrials.gov

Celgene Corporation, a wholly owned subsidiary of Bristol-Myers Squibb Company

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Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • Active, Not Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Cohort A: CC-220 Monotherapy - Part 1
Drug: CC-220
Experimental: Cohort B: CC-220 in combination with Dexamethasone (DEX) - Part 1
Drug: CC-220, Dexamethasone
Experimental: Cohort C: CC-220 Monotherapy in RRMM - Part 2
Drug: CC-220
Experimental: Cohort D: CC-220 in combination with Dexamethasone - Part 2
Drug: CC-220, Dexamethasone
Experimental: Cohort E: CC-220 with DEX and daratumumab (DARA) - Part 1
Drug: CC-220, Dexamethasone, Daratumumab
Experimental: Cohort F: CC-220 with DEX and bortezomib - Part 1
Drug: CC-220, Dexamethasone, Bortezomib
Experimental: Cohort G1: CC-220 in combination with CFZ and DEX - Part 1
Drug: CC-220, Dexamethasone, Carfilzomib
Experimental: Cohort G2 - CC-220 in combination with CFZ and DEX - Part 1
Drug: CC-220, Dexamethasone, Carfilzomib
Experimental: Cohort I: CC-220 in combination with DEX in post BCMA RRMM - Part 2
Drug: CC-220, Dexamethasone
Experimental: Cohort J1: CC-220 in combination with DEX and BTZ in NDMM - Part 2
Drug: CC-220, Dexamethasone, Bortezomib
Experimental: Cohort J2: CC-220 in combination with DEX and BTZ in NDMM - Part 2
Drug: CC-220, Dexamethasone, Bortezomib
Experimental: Cohort K: CC-220 with DEX and DARA in NDMM and not autologous stem cell transplant eligible - Part 2
Drug: CC-220, Dexamethasone, Daratumumab

Key Eligibility Criteria

Inclusion Criteria: - Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2 - Relapsed and refractory multiple myeloma (RRMM) participants must have documented disease progression on or within 60 days from the last dose of their last myeloma therapy - Newly diagnosed multiple myeloma (NDMM) participants must have documented diagnosis with previously untreated symptomatic multiple myeloma (MM) - Participants in Cohorts J1 and K are those for whom autologous stem cell transplantation is not planned for initial therapy or are not considered by the investigator as eligible for high-dose chemotherapy and autologous stem cell transplantation Exclusion Criteria: - Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the participant from participating in the study - Nonsecretory multiple myeloma - Prior history of malignancies, other than MM and select non-invasive malignancies, unless the participant has been free of the disease for ≥ 5 years Other protocol-defined inclusion/exclusion criteria apply

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