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  • NCT06121843

Recruiting

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma - CA088-1005

Updated: 15 July, 2026   |   ClinicalTrials.gov

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Trial Details

  • Phase 1

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 18

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Arm A: BMS-986393 + Alnuctamab
Drug: BMS-986393, Alnuctamab
Experimental: Arm B: BMS-986393 + Mezigdomide
Drug: BMS-986393, Mezigdomide
Experimental: Arm C: BMS-986393 + Iberdomide
Drug: BMS-986393, Iberdomide
Experimental: Arm D: BMS-986393 + Elranatamab
Drug: Elranatamab, BMS-986393
Experimental: Arm E: BMS-986393 + Mezigdomide and Dexamethasone
Drug: Dexamethasone, BMS-986393, Mezigdomide

Key Eligibility Criteria

Inclusion Criteria: - History of relapsed and/or refractory multiple myeloma (RRMM) treated with at least 3 (Part 1), history of RRMM or at least 1 but not greater than 3 prior anti-myeloma treatment (PAMT) regimens (Part 2, Arms A, B, C, and D); history of quadruple class exposed RRMM having received BCMA TCE as the most recent line of therapy (Part 2, Arm E). - Measurable multiple myeloma (MM) as per International Myeloma Working Group (IMWG). - Eastern Cooperative Oncology Group performance status of 0-1. - Adherence to contraception requirements. Exclusion Criteria: - Prior treatment with alnuctamab (Arm A), mezigdomide (Arms B and E), iberdomide (Arm C), elranatamab (Arm D) or BCMA-targeting therapy (Part 2 Arms A and D). - Prior treatment with GPRC5D-targeting therapies as of Protocol Amendment 02 (Part 1 and Part 2). - Other protocol-defined inclusion/exclusion criteria apply.

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