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  • NCT03989414

Active, Not Recruiting

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM) - CC-92480-MM-002

Updated: 3 May, 2024   |   ClinicalTrials.gov

Celgene Corporation, a wholly owned subsidiary of Bristol-Myers Squibb Company

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Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • Active, Not Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Cohort A: CC-92480 with bortezomib and dexamethasone
Drug: CC-92480, Bortezomib, Dexamethasone
Experimental: Cohort C: CC-92480 with carfilzomib and dexamethasone
Drug: CC-92480, Dexamethasone, Carfilzomib
Experimental: Cohort D: CC-92480 with bortezomib and dexamethasone
Drug: CC-92480, Bortezomib, Dexamethasone
Experimental: Cohort F: CC-92480 with carfilzomib and dexamethasone
Drug: CC-92480, Dexamethasone, Carfilzomib
Experimental: Cohort G: CC-92480 with bortezomib and dexamethasone
Drug: CC-92480, Bortezomib, Dexamethasone
Experimental: Cohort H: CC-92480 with elotuzumab and dexamethasone
Drug: CC-92480, Dexamethasone, Elotuzumab
Experimental: Cohort I: CC-92480 with isatuximab and dexamethasone
Drug: CC-92480, Dexamethasone, Isatuximab
Experimental: Cohort J: CC-92480 with elotuzumab and dexamethasone
Drug: CC-92480, Dexamethasone, Elotuzumab
Experimental: Cohort K: CC-92480 with isatuximab and dexamethasone
Drug: CC-92480, Dexamethasone, Isatuximab
Experimental: Subcohort B1: CC-92480 with daratumumab and dexamethasone
Drug: CC-92480, Dexamethasone, Daratumumab
Experimental: Subcohort B2: CC-92480 with daratumumab and dexamethasone
Drug: CC-92480, Dexamethasone, Daratumumab
Experimental: Subcohort B3: CC-92480 with daratumumab and dexamethasone
Drug: CC-92480, Dexamethasone, Daratumumab
Experimental: Subcohort E1: CC-92480 with daratumumab and dexamethasone
Drug: CC-92480, Dexamethasone, Daratumumab
Experimental: Subcohort E2: CC-92480 with daratumumab and dexamethasone
Drug: CC-92480, Dexamethasone, Daratumumab
Experimental: Subcohort E3: CC-92480 with daratumumab and dexamethasone
Drug: CC-92480, Dexamethasone, Daratumumab

Key Eligibility Criteria

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2 For participants in Cohorts A, B, C, D, E, F, H, I, J, and K the following inclusions will also apply: - Documented diagnosis of multiple myeloma (MM) and measurable disease - Documented disease progression during or after their last antimyeloma regimen - Achieved a response (minimal response [MR] or better) to at least 1 prior treatment regimen Exclusion Criteria: - Plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or clinically significant amyloidosis - Known central nervous system (CNS) involvement with myeloma - Received immunosuppressive medication within the last 14 days of initiating study treatment - Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment Other protocol-defined inclusion/exclusion criteria apply

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