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  • NCT03785249

Recruiting

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 - CA239-0008

Updated: 18 September, 2024   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
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SELECT LANGUAGE

Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 100

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Phase 1 Dose Exploration
Drug: MRTX849
Experimental: Phase 1b Expansion
Drug: MRTX849
Experimental: Phase 2
Drug: MRTX849
Experimental: Phase 2 Combination with Cetuximab
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Afatinib
Drug: MRTX849, Afatinib
Experimental: Pilot Phase 1b Combination with Cetuximab
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Cetuximab in NSCLC
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Cetuximab in PDAC
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Pembrolizumab
Drug: MRTX849, Pembrolizumab

Key Eligibility Criteria

Inclusion Criteria: - Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation - Unresectable or metastatic disease - Standard treatment is not available or patient declines; first-line treatment for NSCLC for certain cohorts - Adequate organ function Exclusion Criteria: - History of intestinal disease or major gastric surgery or inability to swallow oral medications - Other active cancer

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Have questions? Call us at 900-150-160 or Email Us

Have questions?
Call us at 900-150-160 or Email Us