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  • NCT06618287

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors - CA244-0001

Updated: 29 July, 2025   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
Print this page CA244-0001
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Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 39

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Group A
Drug: BMS-986507, Osimertinib
Experimental: Group B
Drug: BMS-986507, Pembrolizumab

Key Eligibility Criteria

Inclusion Criteria - Participants must have at least one measurable lesion per response evaluation criteria in solid tumors. - Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. - Participants must have a life expectancy of at least 3 months at the time of the first dose. Exclusion Criteria - Participants must not have any mixed Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) histology. - Participants must not have spinal cord compression, symptomatic central nervous system (CNS) metastases. Progression of existing CNS metastases, or the appearance of new lesions as shown on CNS imaging during screening will be excluded. Participants with CNS metastases discovered during screening may be eligible. - Participants must not have a history of serious recurrent infections. - Participants must not have a history of severe heart disease. - Other protocol-defined Inclusion/Exclusion criteria apply.

If you want to report a side effect, you can report directly to the Danish Medicines Agency via the website www.meldenbivirkning.dk
We recommend that you also contact BMS to report side effects.
Side effects and other reportable events are defined here
Report side effects or product quality complaints: Medical Information

466-DK-2200001