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  • NCT06121843

Recruiting

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma - CA088-1005

Updated: 15 July, 2026   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
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Print this page CA088-1005
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Trial Details

  • Phase 1

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 18

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Arm A: BMS-986393 + Alnuctamab
Drug: BMS-986393, Alnuctamab
Experimental: Arm B: BMS-986393 + Mezigdomide
Drug: BMS-986393, Mezigdomide
Experimental: Arm C: BMS-986393 + Iberdomide
Drug: BMS-986393, Iberdomide
Experimental: Arm D: BMS-986393 + Elranatamab
Drug: Elranatamab, BMS-986393
Experimental: Arm E: BMS-986393 + Mezigdomide and Dexamethasone
Drug: Dexamethasone, BMS-986393, Mezigdomide

Key Eligibility Criteria

Inclusion Criteria: - History of relapsed and/or refractory multiple myeloma (RRMM) treated with at least 3 (Part 1), history of RRMM or at least 1 but not greater than 3 prior anti-myeloma treatment (PAMT) regimens (Part 2, Arms A, B, C, and D); history of quadruple class exposed RRMM having received BCMA TCE as the most recent line of therapy (Part 2, Arm E). - Measurable multiple myeloma (MM) as per International Myeloma Working Group (IMWG). - Eastern Cooperative Oncology Group performance status of 0-1. - Adherence to contraception requirements. Exclusion Criteria: - Prior treatment with alnuctamab (Arm A), mezigdomide (Arms B and E), iberdomide (Arm C), elranatamab (Arm D) or BCMA-targeting therapy (Part 2 Arms A and D). - Prior treatment with GPRC5D-targeting therapies as of Protocol Amendment 02 (Part 1 and Part 2). - Other protocol-defined inclusion/exclusion criteria apply.

If you want to report a side effect, you can report directly to the Danish Medicines Agency via the website www.meldenbivirkning.dk
We recommend that you also contact BMS to report side effects.
Side effects and other reportable events are defined here
Report side effects or product quality complaints: Medical Information

466-DK-2200001