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Recruiting

A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies - CA239-0071

Opdateret: 13 maj, 2026   |   ClinicalTrials.gov

Udskriftsvenligt sammendrag

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Forsøgsdetaljer

  • Phase 2

    Fase

  • Køn

  • 18+

    Aldersinterval

  • 45

    Beliggenhed(er)

  • Recruiting

Behandlingsmuligheder

Forsøgsgrene
TILDELT INTERVENTION
Experimental: Arm A1
Drug: Adagrasib
Experimental: Arm A2
Drug: Adagrasib
Experimental: Arm B1
Drug: Adagrasib, Pembrolizumab
Experimental: Arm B2
Drug: Adagrasib, Pembrolizumab
Experimental: Arm B3
Drug: Adagrasib, Cetuximab
Experimental: Arm B4
Drug: Adagrasib, Pembrolizumab, Pemetrexed
Experimental: Arm C1
Drug: Pembrolizumab
Experimental: Arm C2
Drug: Docetaxel
Experimental: Arm C3
Drug: Irinotecan, Leucovorin, Fluorouracil
Experimental: Arm C4
Drug: Leucovorin, Oxaliplatin, Fluorouracil

Primære egnethedskriterier

Inclusion Criteria: - Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit. - Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF. Exclusion Criteria: - Participant is not eligible for study treatment per the parent study eligibility criteria. - Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study. - Participants not receiving clinical benefit from parent study drug as assessed by the investigator. Other protocol defined inclusion/exclusion criteria applies.

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