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  • NCT07160725

Not Yet Recruiting

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors - CA254-0001

Opdateret: 7 oktober, 2025   |   ClinicalTrials.gov

Udskriftsvenligt sammendrag

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Udskriv denne side CA254-0001
Hente vejledningen til forsøgsdeltagere

VÆLG SPROG

Forsøgsdetaljer

  • Phase 1/Phase 2

    Fase

  • Køn

  • 18+

    Aldersinterval

  • 15

    Beliggenhed(er)

  • Not Yet Recruiting

Behandlingsmuligheder

Forsøgsgrene
TILDELT INTERVENTION
Experimental: Part 1
Drug: BMS-986517
Experimental: Part 2: Cohort A
Drug: BMS-986517
Experimental: Part 2: Cohort B
Drug: BMS-986517
Experimental: Part 2: Cohort C
Drug: BMS-986517

Primære egnethedskriterier

Inclusion Criteria: - Participants must have an ECOG performance status of 0 to 1. - Participants must have measurable disease by RECIST v1.1 (radiologically measured by the Investigator). - Participants must have documented histologically or cytologically confirmed advanced, unresectable/metastatic solid tumors, including NSCLC, HNSCC, TNBC, and HR+/HER2- breast cancer. Exclusion Criteria: - Participants must not have untreated CNS metastases. Participants are eligible if CNS metastases have been treated and do not require immediate treatment or have been treated and have neurologically returned to baseline (except for residual signs or symptoms related to the CNS treatment). - Participants must not have concurrent malignancy (present during Screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment assignment. - Participants must not have history of serious recurrent infections. - Participants must not have impaired cardiac function or history of severe heart disease. - Other protocol-defined inclusion/exclusion criteria apply.

Hvis du vil rapportere en bivirkning, kan du indberette direkte til Lægemiddelstyrelsen via hjemmesiden www.meldenbivirkning.dk
Vi anbefaler at du også kontakter BMS for at rapportere bivirkninger.
Bivirkninger og andre rapporterbare begivenheder er defineret her
Rapporter bivirkninger eller klager over produktkvalitet: Medicinsk information

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