Active, Not Recruiting
A Study to Assess the Effect of CC-95251 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndromes - CA059-001
Opdateret:
1 april, 2024
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ClinicalTrials.gov
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Active, Not Recruiting
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit: www.BMSStudyConnect.com Inclusion Criteria: • Eastern Cooperative Oncology Group Performance Status of 0 to 2 For Parts A & B: - Relapsed or refractory (R/R) acute myeloid leukemia (AML) as defined by the 2016 WHO Classification - R/R myelodysplastic syndromes (MDS) as defined by the 2016 WHO Classification with intermediate, high or very high risk by Revised International Prognostic Scoring System (IPSS-R) For Part C: • Treatment-naïve (ie, previously untreated) MDS as defined by the 2016 WHO Classification with intermediate, high or very high risk by IPSS-R Exclusion Criteria: - Acute promyelocytic leukemia - Immediately life-threatening, severe complications of leukemia such as disseminated/uncontrolled infection, uncontrolled bleeding, and/or uncontrolled disseminated intravascular coagulation - Participants who have received prior treatment with a CD47 or SIRPα targeting agent - Participant is on chronic systemic immunosuppressive therapy or corticosteroids - Prior systemic cancer-directed treatments or investigational modalities ≤ 5 half-lives or 4 weeks prior to starting study treatment, whichever is shorter (relapsed or refractory participants only). - Any condition including, active or uncontrolled infection, or the presence of laboratory abnormalities, which places the participant at unacceptable risk if he/she were to participate in the study - Pregnant or nursing participants. Other protocol-defined inclusion/exclusion criteria apply
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