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  • NCT04817007

Active, Not Recruiting

A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis) - CA011-023

Opdateret: 11 marts, 2024   |   ClinicalTrials.gov

Udskriftsvenligt sammendrag

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Udskriv denne side CA011-023
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VÆLG SPROG

Forsøgsdetaljer

  • Phase 1

    Fase

  • Køn

  • 18+

    Aldersinterval

  • Active, Not Recruiting

Behandlingsmuligheder

Forsøgsgrene
TILDELT INTERVENTION
Experimental: Part 1A: BMS-986158 + Ruxolitinib
Drug: Ruxolitinib, BMS-986158
Experimental: Part 1B: BMS-986158 + Fedratinib
Drug: Fedratinib, BMS-986158
Experimental: Part 2A2 Add-On: BMS-986158 + Ruxolitinib
Drug: Ruxolitinib, BMS-986158
Experimental: Part 2A3: BMS-986158 + Ruxolitinib
Drug: Ruxolitinib, BMS-986158
Experimental: Part 2A: BMS-986158 + Ruxolitinib
Drug: Ruxolitinib, BMS-986158
Experimental: Part 2B1: BMS-986158 + Fedratinib
Drug: Fedratinib, BMS-986158
Experimental: Part 2B2: BMS-986158 Mono and/or (BMS-986158 + Fedratinib), if applicable

Primære egnethedskriterier

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Diagnosis of primary myelofibrosis (PMF), post-essential thrombocythemia (ET) or post-polycythemia vera (PV) myelofibrosis - Treatment-related toxicities from prior therapy resolved to Grade 1 or pre-treatment baseline or determined to be irreversible prior to study treatment - Must agree to follow specific methods of contraception, if applicable Exclusion Criteria: - Women who are pregnant or breastfeeding at screening - Any significant acute or uncontrolled chronic medical illness Other protocol-defined inclusion/exclusion criteria apply

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