Share Icon Health Study Area: Cardiovascular Disease Chevron Icon Health Study Area: Genitourinary For Patients Health Study Area: Lung Cancer Page Icon Phone Icon For Caregivers Health Study Area: AutoImmune Disease Health Study Area: Melanoma Location Icon Print YouTube Icon For Parents Health Study Area: Lung Cancer Print Created with Sketch. Help Icon Green Check Icon Search Icon Instagram Created with sketchtool. Direction Arrow Icon Error Icon For Parents Health Study Area: Blood Cancer Help Icon Health Study Area: NASH Gender Both Bookmark Icon Health Study Area: Melanoma Created with Sketch. Glossary Print Health Study Area: Blood Cancer Health Study Area: Genitourinary Health Study Area: Gastrointestinal Cancer Mobile Menu Icon Created with Sketch. Health Study Area: Cardiovascular Disease Health Study Area: Women's Cancer Communities Map Icon Created with Sketch. For Caregivers Health Study Area: Fibrosis Health Study Area: AutoImmune Disease FAQs Health Study Area: Head and Neck Cancer Created with Sketch. For Clinicians Chevron Right Icon Gender Female Health Study Area: Breast Cancer Direction Arrow Icon Gender Both Right Arrow Icon LinkedIn Icon Green Check Icon Gender Male Health Study Area: Fibrosis For Patients Twitter Icon Email Icon Facebook Icon Health Study Area: Gastrointestinal Cancer Health Study Area: Head and Neck Cancer For Clinicians External Link Icon
Hledat Study Connect

Recruiting

A Study of BMS-986449 With and Without Nivolumab in Participants With Advanced Solid Tumors - CA120-1001

Updated: 22 říjen, 2024   |   ClinicalTrials.gov

Tisk přehledného shrnutí

ZVAŽUJETE TOTO HODNOCENÍ?
Vytiskněte si tuto stránku a průvodce hodnocením, pomůže vám to při rozhovoru s lékařem.
Pomocí průvodce hodnocením se můžete pohybovat procesem účasti na klinickém hodnocení. Než se rozhodnete, zjistěte si, jaké jsou klíčové faktory, a připravte si otázky pro zdravotnický tým.

Podrobnosti o hodnocení

  • Phase 1/Phase 2

    Fáze

  • Pohlaví

  • 18+

    Věková skupina

  • 13

    Umístění

  • Recruiting

Možnosti léčby

Ramena studie
Přiřazená léčba
Experimental: Dose Escalation: BMS-986449 + nivolumab
Drug: BMS-986449, Nivolumab
Experimental: Dose Escalation: BMS-986449 monotherapy
Drug: BMS-986449
Experimental: Dose Escalation: BMS-986449 monotherapy pharmacodynamic (PD) cohorts
Drug: BMS-986449

Klíčová kritéria způsobilosti

Inclusion Criteria: - All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy (measurable by Response Evaluation Criteria in Solid Tumors [RECIST] v1.1), and have received, be refractory to, ineligible for, or intolerant of existing therapy(ies) known to provide clinical benefit for the condition of the participant. - Part 1A may have a solid malignancy of any histology. - Part 1B is restricted to participants with Non-small cell lung cancer (NSCLC). - Part 1C is restricted to participants with Triple-negative breast cancer (TNBC). - Tumor biopsy must be obtained for all participants (unless medically precluded). Exclusion Criteria: - History of Grade ≥ 3 toxicity related to prior T-cell agonist or checkpoint inhibitor therapy (eg, anti-cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4], or anti-PD- 1/programmed death-ligand 1 [PD-L1] treatment, or any other antibody or drug specifically targeting T-cell co-stimulation or other immune checkpoint pathways) except those that are unlikely to re-occur with standard countermeasures. - Current or recent (within 3 months of study intervention administration) gastrointestinal disease or gastrointestinal surgery (eg, intestinal/gastric/colon resection) that could impact the absorption of study intervention. - Any significant acute or chronic medical illness which would interfere with study intervention or follow-up in the opinion of the investigator. Other protocol-defined criteria may apply.

Důrazně doporučujeme kontaktovat BMS a oznámit vedlejší účinky / nežádoucí příhody
Zde jsou definovány vedlejší účinky / nežádoucí příhody a další příhody, které by měly být hlášeny
Nahlásit vedlejší účinky / nežádoucí příhody nebo stížnosti na kvalitu produktu: lékařské informace

Máte otázky? Pošlete nám e-mail

Máte otázky?
Pošlete nám e-mail