Inclusion Criteria
- Participants must have a multiple sclerosis (MS) diagnosis.
- Participants must have a history of spasticity due to MS for at least 6 months prior
to Visit 1.
- Participants must have a Modified Ashworth Scale (mAS) score ≥2 in each of 2 muscle
groups (at least one muscle group in the leg, excluding ankle plantar flexors) at
Visit 1.
- Participants must have an Expanded Disability Status Scale (EDSS) score 3.0-6.5 at
Visit 1.
Exclusion Criteria
- Participants must not have any concomitant disease or disorder that has symptoms of
spasticity or that may influence the participant's level of spasticity.
- Participants must not have an acute MS exacerbation/relapse requiring treatment or
alteration in disease modifying drug dose within 3 months of Visit 1 or Visit 2.
- Participants must not have a history of any substance abuse disorder.
- Participants must not be currently taking a medication for spasticity that cannot be
discontinued and washed out by Visit 2.
- Participants must not have used cannabinoid-related products (including cannabis,
cannabidiol (CBD), or tetrahydrocannabinol (THC)) within 30 days prior to Visit 1.
- Other protocol-defined Inclusion/Exclusion criteria apply.
