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Active, Not Recruiting

A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors - CA233-0000

Aggiornato: 14 aprile, 2026   |   ClinicalTrials.gov.

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SELEZIONI UNA LINGUA

Dettagli della sperimentazione

  • Phase 1

    Fase

  • Sesso

  • 18+

    Fascia d'età

  • Active, Not Recruiting

Opzioni di trattamento

Bracci dello studio
INTERVENTO ASSEGNATO
Experimental: Part 1 Co-Admin: BMS-986484 + Nivolumab
Drug: BMS-986484 Biological: Nivolumab
Experimental: Part 1A: BMS-986484 Dose Escalation
Drug: BMS-986484
Experimental: Part 1B: BMS-986484 + Nivolumab Dose Escalation
Drug: BMS-986484 Biological: Nivolumab
Experimental: Part 1C: BMS-986484 + Nivolumab + Chemotherapy Dose Escalation
Drug: Oxaliplatin, Capecitabine, Fluorouracil, Calcium folinate, BMS-986484 Biological: Nivolumab
Experimental: Part 1SC: BMS-986484 Monotherapy Subcutaneous Dose Escalation
Drug: BMS-986484
Experimental: Part 2A: BMS-986484 Dose Expansion
Drug: BMS-986484
Experimental: Part 2B: BMS-986484 + Nivolumab Dose Expansion
Drug: BMS-986484 Biological: Nivolumab
Experimental: Part 2C: BMS-986484 + Nivolumab + Chemotherapy Dose Expansion
Drug: Oxaliplatin, Capecitabine, Fluorouracil, Calcium folinate, BMS-986484 Biological: Nivolumab

Principali criteri di idoneità

Inclusion Criteria: - Locally advanced unresectable, metastatic, or recurrent malignant tumors including non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDAC), gastric/gastroesophageal junction adenocarcinoma (G/GEJC), microsatellite stable colorectal cancer (MSS CRC), and squamous cell carcinoma of the head and neck (SCCHN). - Must have measurable disease by response evaluation criteria in solid tumors version 1.1 (RECIST v1.1). - Must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1. Exclusion Criteria: - History of or with active interstitial lung disease or pulmonary fibrosis. - Active, known, or suspected autoimmune disease. - Serious uncontrolled medical disorders. - New onset, non-catheter-associated venous thromboembolism within the past 6 months. - Other protocol-defined Inclusion/Exclusion criteria apply.