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Cerca in Study Connect
  • NCT03785249

Recruiting

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 - CA239-0008

Aggiornato: 18 giugno, 2024   |   ClinicalTrials.gov.

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SELEZIONI UNA LINGUA

Dettagli della sperimentazione

  • Phase 1/Phase 2

    Fase

  • Sesso

  • 18+

    Fascia d'età

  • 101

    Sede/i

  • Recruiting

Opzioni di trattamento

Bracci dello studio
INTERVENTO ASSEGNATO
Experimental: Phase 1 Dose Exploration
Drug: MRTX849
Experimental: Phase 1b Expansion
Drug: MRTX849
Experimental: Phase 2
Drug: MRTX849
Experimental: Phase 2 Combination with Cetuximab
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Afatinib
Drug: Afatinib, MRTX849
Experimental: Pilot Phase 1b Combination with Cetuximab
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Cetuximab in NSCLC
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Cetuximab in PDAC
Drug: Cetuximab, MRTX849
Experimental: Pilot Phase 1b Combination with Pembrolizumab
Drug: MRTX849, Pembrolizumab

Principali criteri di idoneità

Inclusion Criteria: - Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation - Unresectable or metastatic disease - Standard treatment is not available or patient declines; first-line treatment for NSCLC for certain cohorts - Adequate organ function Exclusion Criteria: - History of intestinal disease or major gastric surgery or inability to swallow oral medications - Other active cancer

Ti consigliamo vivamente di contattare BMS per segnalare gli effetti collaterali (eventi avversi)
Qui vengono definiti gli effetti collaterali (eventi avversi) e altri eventi da segnalare
Segnala effetti collaterali (eventi avversi) o reclami sulla qualità del prodotto: informazioni mediche