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Rechercher Study Connect
  • NCT07204418

Not Yet Recruiting

A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants - CN012-0012

Mis à jour: 24 septembre, 2025   |   ClinicalTrials.gov

Résumé imprimable

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Détails de l’essai

  • Phase 1

    Phase

  • Sexe(s)

  • 18-65

    Tranche d’âge

  • 3

    Site(s)

  • Not Yet Recruiting

Options de traitement

Bras de l’étude
INTERVENTION ASSIGNÉE
Experimental: KarXT
Drug: Xanomeline/ Trospium Chloride

Principaux critères d’éligibilité

Inclusion Criteria: - Participant must be healthy male and female (INOCBP) participants as determined by no clinically significant deviation from normal in medical history, physical examination, 12-lead electrocardiogram (ECG), vital signs (VS), and clinical laboratory determinations. - Participant must be a normal/extensive, intermediate, poor, or ultrarapid CYP2D6 metabolizer. - Participant must have body mass index (BMI) of 18.0 to 32.0 kg/m2, inclusive. Exclusion Criteria: - Participants must not have evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, 12-lead ECG, or clinical laboratory determinations beyond what is consistent with the target population reference ranges. - Other protocol-defined Inclusion/Exclusion criteria apply.

Nous vous recommandons vivement de contacter BMS pour signaler les effets secondaires (événements indésirables)
Les effets secondaires (événements indésirables) et les autres événements à signaler sont définis ici
Signaler des plaintes concernant des effets indésirables (effets indésirables) ou des produits: Informations médicales