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Rechercher Study Connect

Recruiting

A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors - CA234-0001

Mis à jour: 2 avril, 2025   |   ClinicalTrials.gov

Résumé imprimable

VOUS ENVISAGEZ CET ESSAI ?
Imprimer cette page et le guide d’essai pour vous aider à parler avec votre médecin.
Utiliser le Guide du participant à l’étude pour découvrir comment participer à un essai clinique. Comprendre les principaux facteurs à envisager avant de prendre une décision et poser des questions à votre équipe soignante.

Détails de l’essai

  • Phase 1

    Phase

  • Sexe(s)

  • 18+

    Tranche d’âge

  • 8

    Site(s)

  • Recruiting

Options de traitement

Bras de l’étude
INTERVENTION ASSIGNÉE
Experimental: Part 1A: BMS-986488 Monotherapy
Drug: BMS-986488
Experimental: Part 1B: BMS-986488 + Adagrasib
Drug: BMS-986488, Adagrasib
Experimental: Part 1C: BMS-986488 + Adagrasib + Cetuximab
Drug: BMS-986488, Adagrasib, Cetuximab
Experimental: Part 1D: BMS-986488 + Nivolumab
Drug: BMS-986488, Nivolumab
Experimental: Part 2A: BMS-986488 Monotherapy
Drug: BMS-986488
Experimental: Part 2B: BMS-986488 + Adagrasib
Drug: BMS-986488, Adagrasib
Experimental: Part 2C: BMS-986488 + Adagrasib + Cetuximab
Drug: BMS-986488, Adagrasib, Cetuximab
Experimental: Part 2D: BMS-986488 + Nivolumab
Drug: BMS-986488, Nivolumab

Principaux critères d’éligibilité

Inclusion Criteria: - Participant must be ≥ 18 years of age. - Histologically confirmed diagnosis of a locally advanced and unresectable or metastatic solid tumor malignancy with any of the following tumor types:. - Part 1A: clear-cell renal cell carcinoma (ccRCC) or clear-cell ovarian cancer (ccOC). - Parts 2A, 1D, 2D: ccRCC. i) Part 1B: solid tumors with KRAS G12C mutation. ii) Part 2B: NSCLC with KRAS G12C mutation. iii) Parts 1C, 2C: colorectal cancer (CRC) with KRAS G12C mutation. - Participants must have an Eastern Cooperative Oncology Groups (ECOG) Performance Status of 0 or 1. - Participants must have measurable disease per RECIST v1.1. Exclusion Criteria: - Untreated central nervous system (CNS) metastases. - Leptomeningeal metastasis (carcinomatous meningitis). - Impaired cardiac function or clinically significant cardiac disease. - For Parts 1B, 1C, 2B, 2C only (combination with adagrasib):. i) History of pneumonitis or interstitial lung disease (ILD). ii) History of prior severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). - Other protocol-defined inclusion/exclusion criteria apply.

Nous vous recommandons vivement de contacter BMS pour signaler les effets secondaires (événements indésirables)
Les effets secondaires (événements indésirables) et les autres événements à signaler sont définis ici
Signaler des plaintes concernant des effets indésirables (effets indésirables) ou des produits: Informations médicales