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Rechercher Study Connect
  • NCT06746402

Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of BMS-986278 and the Effects of BMS-986278 on Cardiac Repolarization in Healthy Participants - IM027-1012

Mis à jour: 7 mars, 2025   |   ClinicalTrials.gov

Résumé imprimable

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SÉLECTIONNER LA LANGUE

Détails de l’essai

  • Phase 1

    Phase

  • Sexe(s)

  • 18-55

    Tranche d’âge

  • 2

    Site(s)

  • Recruiting

Options de traitement

Bras de l’étude
INTERVENTION ASSIGNÉE
Experimental: Part A
Drug: BMS-986278, Placebo
Experimental: Part B1/B2 Treatment A
Drug: BMS-986278
Experimental: Part B1/B2 Treatment B
Drug: BMS-986278, Placebo
Experimental: Part B1/B2 Treatment C
Drug: Placebo
Experimental: Part B1/B2 Treatment D
Drug: Placebo, Moxifloxacin
Experimental: Part B3 Treatment A
Drug: BMS-986278
Experimental: Part B3 Treatment B
Drug: BMS-986278, Placebo
Experimental: Part B3 Treatment C
Drug: Placebo
Experimental: Part B3 Treatment D
Drug: Placebo, Moxifloxacin

Principaux critères d’éligibilité

Inclusion Criteria: - Female individuals not of childbearing potential (INOCBP) and males. - Healthy as determined by medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory assessments. - Body mass index (BMI) 18.0 to 32.0 kg/m2 , inclusive, for Parts A and B. Exclusion Criteria: - Any significant acute or chronic medical illness as determined by the investigator. - History of clinically relevant cardiac disease as determined by the investigator, symptomatic or asymptomatic arrhythmias, presyncope or syncopal episodes, or additional risk factors for ventricular arrhythmias. - Any significant history of disease of the cardiovascular system that in the opinion of the Investigator makes the participant unsuitable for enrollment into the study. - Other protocol-defined inclusion/exclusion criteria apply.

Nous vous recommandons vivement de contacter BMS pour signaler les effets secondaires (événements indésirables)
Les effets secondaires (événements indésirables) et les autres événements à signaler sont définis ici
Signaler des plaintes concernant des effets indésirables (effets indésirables) ou des produits: Informations médicales