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Active, Not Recruiting

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 - CA239-0008

Mis à jour: 28 juillet, 2026   |   ClinicalTrials.gov

Résumé imprimable

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Utiliser le Guide du participant à l’étude pour découvrir comment participer à un essai clinique. Comprendre les principaux facteurs à envisager avant de prendre une décision et poser des questions à votre équipe soignante.
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SÉLECTIONNER LA LANGUE

Détails de l’essai

  • Phase 1/Phase 2

    Phase

  • Sexe(s)

  • 18+

    Tranche d’âge

  • Active, Not Recruiting

Options de traitement

Bras de l’étude
INTERVENTION ASSIGNÉE
Experimental: Phase 1 Dose Exploration
Drug: MRTX849
Experimental: Phase 1b Expansion
Drug: MRTX849
Experimental: Phase 2
Drug: MRTX849
Experimental: Phase 2 Combination with Cetuximab
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Afatinib
Drug: MRTX849, Afatinib
Experimental: Pilot Phase 1b Combination with Cetuximab
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Cetuximab in NSCLC
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Cetuximab in PDAC
Drug: MRTX849, Cetuximab
Experimental: Pilot Phase 1b Combination with Pembrolizumab
Drug: MRTX849, Pembrolizumab

Principaux critères d’éligibilité

Inclusion Criteria: - Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation - Unresectable or metastatic disease - Standard treatment is not available or patient declines; first-line treatment for NSCLC for certain cohorts - Adequate organ function Exclusion Criteria: - History of intestinal disease or major gastric surgery or inability to swallow oral medications - Other active cancer