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Pesquisa Study Connect
  • NCT07680790

Not Yet Recruiting

Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02) - CA244-0020

Atualizado: 26 junho, 2026   |   ClinicalTrials.gov

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Detalhes do estudo

  • Phase 3

    Fase

  • Gênero(s)

  • 18+

    Faixa etária

  • 83

    Localização(ões)

  • Not Yet Recruiting

Opções de tratamento

Braços de tratamento do Estudo
INTERVENÇÃO ATRIBUÍDA
Experimental: Arm A
Drug: Iza-bren, Osimertinib
Active Comparator: Arm B
Drug: Osimertinib, Pemetrexed, Carboplatin, Cisplatin

Principais critérios de elegibilidade

Inclusion Criteria: - Participants must have histologically or cytologically confirmed non-squamous NSCLC, newly diagnosed locally advanced (Stage IIIB/IIIC), metastatic (Stage IVA/IVB), or recurrent disease not amenable to curative surgery or definitive radiotherapy and requiring systemic treatment - Participants must have documented EGFR-TKI-sensitizing mutation (exon 19 deletion or exon 21 L858R substitution) - Participants must have measurable extracranial disease per RECIST v1.1 as assessed by the investigator - Participants must have ECOG Performance Status 0-1 Exclusion Criteria: - Participants must not have unstable, symptomatic, or uncontrolled CNS metastases, including brain, leptomeningeal disease, and/or spinal cord compression - Participants must not have history of ILD/pneumonitis requiring treatment with steroids (≥ Grade 2), or current or suspected ILD/pneumonitis - Participants must not have clinically significant cardiac disease - Other protocol-defined inclusion/exclusion criteria apply.

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Efeitos colaterais (eventos adversos) e outros eventos relatáveis estão definidos aqui.
Relate efeitos colaterais (eventos adversos) ou reclamações sobre a qualidade do produto: Informações médicas

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