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Pesquisa Study Connect

Active, Not Recruiting

First-In-Human Study of Monoclonal Antibody BMS-986218 by Itself and in Combination With Nivolumab in Patients With Advanced Solid Tumors - CA022-001

Atualizado: 2 janeiro, 2024   |   ClinicalTrials.gov

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Detalhes do estudo

  • Phase 1/Phase 2

    Fase

  • Gênero(s)

  • 18+

    Faixa etária

  • Active, Not Recruiting

Opções de tratamento

Braços de tratamento do Estudo
INTERVENÇÃO ATRIBUÍDA
Experimental: BMS-986218 Monotherapy
Biological: Ipilimumab, BMS-986218
Experimental: Combination Therapy
Biological: Nivolumab, BMS-986218
Experimental: Monotherapy
Biological: BMS-986218
Experimental: Part 2B: Monotherapy (BMS-986218)
Biological: BMS-986218
Experimental: Part 2C: Expansion Combination Therapy (BMS-986218 + Nivolumab)
Biological: Nivolumab, BMS-986218
Experimental: Part 2D: Expansion Combination Therapy (BMS-986218 + Nivolumab)
Biological: Nivolumab, BMS-986218

Principais critérios de elegibilidade

Inclusion Criteria: - For more information regarding Bristol Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com - histologic or cytologic confirmation of a solid tumor that is advanced (metastatic, recurrent and/or unresectable) - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Participants must have received, and then progressed, relapsed, or been intolerant to, all standard treatment regimens with proven survival benefit in the advanced or metastatic setting according to tumor type, if such a therapy exists Exclusion Criteria: - Participants with primary CNS malignancies, or tumors with CNS metastases as the only site of disease, will be excluded - Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior anti-cancer therapy and initiation of study therapy - Prior anti-cancer treatments such as chemotherapy, radiotherapy, hormonal, or immunotherapy (including anti-PD-1/PD-L1) are permitted Other protocol defined inclusion/exclusion criteria could apply

É altamente recomendável que você entre em contato com a BMS para relatar efeitos colaterais (eventos adversos).
Efeitos colaterais (eventos adversos) e outros eventos relatáveis estão definidos aqui.
Relate efeitos colaterais (eventos adversos) ou reclamações sobre a qualidade do produto: Informações médicas

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