Inclusion Criteria
- Mild cognitive impairment (MCI) due to Alzheimer's disease (AD) or mild AD dementia
consistent with the National Institute on Aging and the Alzheimer's Association
(NIA-AA) core clinical criteria.
- Global Clinical Dementia Rating (CDR) score of 0.5 to 1.0 and a CDR-Memory Box score
of 0.5 and greater at screening and Baseline.
- Evidence of AD pathology.
- Objective impairment in episodic memory as indicated by at least 1 standard deviation
below age-adjusted mean in the Wechsler Memory Scale IV-Logical Memory Subtest II
(WMS-IV LM II).
- Mini Mental Status Examination (MMSE) score ≥ 22 to 30 (inclusive).
Exclusion Criteria
- Any evidence of a condition that may affect cognition other than AD.
- Contraindications to PET imaging.
- Inability to tolerate or contraindication to magnetic resonance imaging.
- Any serious medical condition that could, in the opinion of the investigator, affect
the participant's safety or interfere with study assessments.
- Geriatric Depression Scale (GDS) score greater than or equal to 8 at screening.
- Other protocol-defined Inclusion/Exclusion criteria apply.
