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  • NCT05543629

Recruiting

A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer - CA115-001

Updated: 12 May, 2023   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
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Print this page CA115-001
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Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 27

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Part A: BMS-986442 + Nivolumab
Biological: Nivolumab Biological: BMS-986442
Experimental: Part B1: BMS-986442 + Nivolumab
Biological: Nivolumab Biological: BMS-986442
Experimental: Part B2: BMS-986442 + Nivolumab
Biological: Nivolumab Biological: BMS-986442
Experimental: Part C: BMS-986442 + Nivolumab + Docetaxel
Biological: BMS-986442 Drug: Docetaxel Biological: Nivolumab
Experimental: Part D: BMS-986442 + Nivolumab + Carboplatin + Pemetrexed
Biological: BMS-986442 Drug: Pemexetred Drug: Carboplatin Biological: Nivolumab
Experimental: Part E: BMS-986442 + Nivolumab + Carboplatin + Paclitaxel
Biological: BMS-986442 Drug: Paclitaxel Drug: Carboplatin Biological: Nivolumab

Key Eligibility Criteria

Inclusion Criteria: - Participants in all parts of the study must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. - Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. - Participants must have a life expectancy of at least 3 months at the time of first dose. Exclusion Criteria: - Untreated symptomatic central nervous system metastases or leptomeningeal metastases. - Concurrent malignancy (present during screening) requiring treatment, or history of prior malignancy active within 2 years prior to randomization in study Part B1 or treatment assignment in all other study parts. - Participants with an active, known, or suspected autoimmune disease. Other protocol-defined inclusion/exclusion criteria apply.

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