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  • NCT03994601

Recruiting

An Investigational Immunotherapy Study of BMS-986288 Alone and in Combination With Nivolumab in Advanced Solid Cancers - CA043-001

Updated: 5 September, 2023   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
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Print this page CA043-001
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SELECT LANGUAGE

Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 39

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Arm A: BMS-986288 Monotherapy
Drug: BMS-986288
Experimental: Arm B: BMS-986288 in combination with Nivolumab
Drug: BMS-986288 Drug: Nivolumab
Experimental: Part 2C: BMS-986288 in combination with Nivolumab and Regorafenib
Drug: Regorafenib Drug: BMS-986288 Drug: Nivolumab

Key Eligibility Criteria

Inclusion Criteria: - Histologic or cytologic confirmation of select solid tumor that is advanced (metastatic, recurrent, and/or unresectable) with measurable disease and have at least 1 lesion accessible for biopsy - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Received, and then progressed, relapsed, or been intolerant to, at least 1 standard treatment regimen in the advanced or metastatic setting according to select solid tumor histologies Exclusion Criteria: - Active, known or suspected autoimmune disease - Active malignancy requiring concurrent intervention - Primary Central Nervous System (CNS) malignancies or tumors with CNS metastasis as the only site of disease, will be excluded Other protocol-defined inclusion/exclusion criteria apply

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