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Active, Not Recruiting

A Study of BMS-986249 Alone and in Combination With Nivolumab in Advanced Solid Tumors - CA030-001

Updated: 3 October, 2023   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
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Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • Active, Not Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Part 1A: BMS-986249
Biological: BMS-986249
Experimental: Part 1B: BMS-986249 + nivolumab (nivo)
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm A: BMS-986249 + nivo then nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm B: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm C: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2A Arm D: ipilimumab + nivo then nivo
Biological: Ipilimumab, Nivolumab
Experimental: Part 2A Arm E: Nivo
Biological: Nivolumab
Experimental: Part 2A Arm F: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2B Cohort 1: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2B Cohort 2: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249
Experimental: Part 2B Cohort 3: BMS-986249 + nivo
Biological: Nivolumab, BMS-986249

Key Eligibility Criteria

Inclusion Criteria: - Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic, recurrent, and/or unresectable) with measurable disease or metastatic disease documented by either bone lesions on radionuclide bone scan and/or soft tissue lesions on CT/MRI for prostate cancer and have at least 1 lesion accessible for biopsy. For Part 2B participants with HCC, intermediate disease is allowed. - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Must have received, and then progressed, relapsed, or been intolerant to, at least 1 standard treatment regimen in the advanced or metastatic setting according to tumor type, if such a therapy exists - Prior anti-cancer treatments such as chemotherapy, radiotherapy, or hormonal are permitted for some participants - Willing and able to comply with all study procedures Exclusion Criteria: - Primary central nervous system (CNS) malignancies, tumors with CNS metastases as the only site of disease or active brain metastases will be excluded - Other active malignancy requiring concurrent intervention - Prior organ allograft - Active, known, or suspected autoimmune disease Other protocol-defined inclusion/exclusion criteria apply

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