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A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Patients With Advanced Solid Tumors - CV202-103

Updated: 17 August, 2020   |   ClinicalTrials.gov

Print Friendly Summary

Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1/Phase 2


  • Gender(s)

  • 18+

    Age Range

  • 10


  • Recruiting

Treatment Options

Study Arms
Experimental: Combination Therapy 1
Drug: BMS-813160 Drug: 5-fluorouracil (5-FU) Drug: Leucovorin Drug: Irinotecan
Experimental: Combination Therapy 2
Drug: BMS-813160 Drug: Nab-paclitaxel Drug: Gemcitabine
Experimental: Combination Therapy 3
Drug: BMS-813160 Biological: Nivolumab
Experimental: Combination Therapy 4
Drug: BMS-813160
Experimental: Combination Therapy 5
Drug: 5-fluorouracil (5-FU) Drug: Leucovorin Drug: Irinotecan
Experimental: Combination Therapy 6
Drug: Nab-paclitaxel Drug: Gemcitabine
Experimental: Monotherapy
Drug: BMS-813160

Key Eligibility Criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Participants must have metastatic colorectal or pancreatic cancer - Eastern Cooperative Oncology Group (ECOG) performance status of ≤1 - Ability to swallow pills or capsules - All participants will be required to undergo mandatory pre and on-treatment biopsies - Adequate marrow function - Adequate other organ functions - Ability to comply with study visits, treatment, procedures, PK and PD sample collection, and required study follow-up Exclusion Criteria: - Histology other than adenocarcinoma (neuroendocrine or acinar cell) - Suspected, known, or progressive CNS metastases (Imaging required only if participants are symptomatic) - Participants with active, known or suspected autoimmune disease - Participants with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study treatment administration - Interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected treatment-related pulmonary toxicity - Prior treatment with CCR2 and/or CCR5 inhibitors, PD-1, PD(L)-1 or CTLA-4 antibodies - History of allergy to study treatments or any of its components of the study arm that participant is enrolling Other protocol defined inclusion/exclusion criteria could apply

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Side Effects (Adverse Events) and other reportable events are defined here
Report Side Effects (Adverse Events) or Product Quality Complaints: Medical Information

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