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  • NCT02341625

Active, Not Recruiting

A Study of BMS-986148 in Patients With Select Advanced Solid Tumors - CA008-002

Updated: 8 June, 2020   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
Print this page CA008-002
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Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • Active, Not Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Part 1: Ascending dose of BMS-986148
Drug: BMS-986148
Experimental: Part 2: Expansion dose of BMS-986148
Drug: BMS-986148
Experimental: Part 3A: Ascending dose of BMS-986148
Biological: Nivolumab Drug: BMS-986148
Experimental: Part 3B: Expansion dose of BMS-986148
Biological: Nivolumab Drug: BMS-986148

Key Eligibility Criteria

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Must have pancreatic, ovarian, gastric, non-small cell cancer or mesothelioma. For dose expansion, must have tumor that is positive for mesothelin - Expected to have life expectancy of at least 3 months - Men and women 18 years old or older (or local age of majority) - Must have measurable tumor per Response Evaluation Criteria In Solid Tumors (RECIST) or modified RECIST for malignant pleural mesothelioma - ECOG of 0 to 1 Exclusion Criteria: - Cancer metastases in the brain - Moderate eye disorders - Active infection or past hepatitis B or C infection - Major surgery less than 1 month before the start of the study - Uncontrolled heart disease - Impaired liver or bone marrow function - History of allergy to mesothelin-directed antibodies, tubulysin, monoclonal antibodies, nivolumab or related compounds

We strongly recommend you contact BMS to report Side Effects (Adverse Events)
Side Effects (Adverse Events) and other reportable events are defined here
Report Side Effects (Adverse Events) or Product Quality Complaints: Medical Information

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