Inclusion Criteria:
Key Inclusion Criteria:
Part 1:
- Individuals with a confirmed diagnosis of advanced KRAS G12C mutant NSCLC, CRC, PDAC
and BTC that has spread to other parts of the body and cannot be removed surgically,
may or may not have received previous treatment with KRAS G12C inhibitors.
- For NSCLC and CRC: Individuals must have a documented KRAS G12C mutation status from
NYS or FDA approved/cleared or CE marked test or, when such result is not available,
positive KRAS G12C mutation status should be confirmed by a central laboratory in
blood sample collected at the time of screening.
- For PDAC and BTC: Participants must have a documented KRAS G12Cmutation from NYS or
FDA-approved/cleared, or CE-marked test and blood samples will be collected only for
retrospective testing.
- Are relapsed or refractory to available standard of care treatments.
Part 2:
- Individuals with a confirmed diagnosis of advanced KRAS G12C-mutant NSCLC (Part 2A) or
CRC (Part 2B) that has spread to other parts of the body and cannot be removed
surgically and have not received previous treatment with KRAS inhibitors.
- Individuals must have a documented KRAS G12C mutation from FDA or NYS approved/
cleared or CE marked test or, when such result is not available, positive KRAS G12C
mutation status should be confirmed by a central laboratory in blood sample and /or
tumor samples collected at the time of screening or from archival biopsies (less than
1 year old).
- Have failed or disease recurrence or are not able to tolerate after at least 1
pervious line of therapy.
Key Exclusion Criteria:
- Have tumors with known BARF V600X, PTPN11 or KRASQ61X mutations.
- Have or any significant heart disease or condition.
- Receiving any medications that are substrate of CYP3A4 or inducers and/ or inhibitors
Note: Other protocol-defined inclusion/exclusion criteria apply.
Recruiting
