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Trial ID CA115-001  |   NCT05543629

A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer

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Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • BMS Active Not Yet Recruiting Study icon
    Active, Not Recruiting

Overview

The purpose of this study is to evaluate BMS-986442 in combination with nivolumab (with or without chemotherapy) for its antitumor efficacy and benefit to participants.

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Key Eligibility Criteria

Inclusion Criteria: - Participants in all parts of the study must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. - Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. - Participants must have a life expectancy of at least 3 months at the time of first dose. Exclusion Criteria: - Untreated symptomatic central nervous system metastases or leptomeningeal metastases. - Concurrent malignancy (present during screening) requiring treatment, or history of prior malignancy active within 2 years prior to randomization in study Part B1 or treatment assignment in all other study parts. - Participants with an active, known, or suspected autoimmune disease. Other protocol-defined inclusion/exclusion criteria apply.

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Part A: BMS-986442 + Nivolumab

ASSIGNED INTERVENTION
  • Biological: Nivolumab, BMS-986442

Study Arms

Experimental: Part B1: BMS-986442 + Nivolumab

ASSIGNED INTERVENTION
  • Biological: BMS-986442, Nivolumab

Study Arms

Experimental: Part B2: BMS-986442 + Nivolumab

ASSIGNED INTERVENTION
  • Biological: BMS-986442, Nivolumab

Study Arms

Experimental: Part C: BMS-986442 + Nivolumab + Docetaxel

ASSIGNED INTERVENTION
  • Biological: BMS-986442, Nivolumab
  • Drug: Docetaxel

Study Arms

Experimental: Part D: BMS-986442 + Nivolumab + Carboplatin + Pemetrexed

ASSIGNED INTERVENTION
  • Biological: BMS-986442, Nivolumab
  • Drug: Pemexetred, Carboplatin

Study Arms

Experimental: Part E: BMS-986442 + Nivolumab + Carboplatin + Paclitaxel

ASSIGNED INTERVENTION
  • Biological: BMS-986442, Nivolumab
  • Drug: Carboplatin, Paclitaxel