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Recruiting

A Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Single-dose of Mavacamten in Healthy Participants - CV027-043

Updated: 17 July, 2022   |   ClinicalTrials.gov

Print Friendly Summary

CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1

    Phase

  • Gender(s)

  • 18-60

    Age Range

  • 1

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Mavacamten
Drug: Mavacamten
Experimental: Mavacamten and activated charcoal with sorbitol - Dose A
Drug: Activated Charcoal with Sorbitol Drug: Mavacamten
Experimental: Mavacamten and activated charcoal with sorbitol - Dose B
Drug: Mavacamten Drug: Activated Charcoal with Sorbitol

Key Eligibility Criteria

Inclusion Criteria: - Body mass index between 18 and 30 kg/m^2, inclusive, at the Screening Visit - Healthy, as determined by physical examination, vital signs, electrocardiograms (ECGs), and clinical laboratory assessments Exclusion Criteria: - Current or recent (within 3 months of study intervention administration) gastrointestinal disease - History of sorbitol or fructose intolerance or inability to tolerate activated charcoal - History of any significant drug allergy (such as anaphylaxis or hepatotoxicity) Other protocol-defined inclusion/exclusion criteria apply

We strongly recommend you contact BMS to report Side Effects (Adverse Events)
Side Effects (Adverse Events) and other reportable events are defined here
Report Side Effects (Adverse Events) or Product Quality Complaints: Medical Information

Have questions? Live support is available 24/7 - Call 855-907-3286 or email clinical.trials@bms.com

Have questions? Live support is available 24/7 -
Call 855-907-3286 or email clinical.trials@bms.com