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Not Yet Recruiting

A Study of BMS-986406 as Monotherapy and Combination Therapies in Participants With Advanced Tumors - CA111-001

Updated: 17 March, 2022   |   ClinicalTrials.gov

Print Friendly Summary

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Trial Details

  • Phase 1

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 8

    Location(s)

  • Not Yet Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Part 1A: BMS-986406 (Monotherapy Dose Escalation)
Biological: BMS-986406
Experimental: Part 1B: BMS-986406 + Nivolumab (Combination Dose Escalation)
Biological: BMS-986406 Biological: Nivolumab
Experimental: Part 1C: BMS-986406 + Nivolumab (Indication-Specific Dose Expansion)
Biological: BMS-986406 Biological: Nivolumab
Experimental: Part 2: BMS-986406 + Nivolumab (Expansion Cohorts)
Biological: Nivolumab Biological: BMS-986406

Key Eligibility Criteria

Inclusion Criteria: - Histologically or cytologically confirmed locally advanced unresectable, metastatic, or recurrent malignant tumor. Eligible tumor types are non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), pancreatic ductal adenocarcinoma (PDAC), gastric/gastroesophageal junction, castration-resistant prostate cancer (CRPC), ovarian, squamous cell carcinoma of the head and neck (SCCHN), bladder, melanoma, mesothelioma, triple negative breast cancer (TNBC), and soft tissue sarcoma, except for participants with tumors with central nervous system (CNS) metastases as the only site of active disease - Measurable disease by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1), Prostate Cancer Working Group 3 (PCWG3) (for prostate cancer), or modified Response Evaluation Criteria in Solid tumors (mRECIST) (for mesothelioma) - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Adequate organ function Exclusion Criteria: - Prior organ or tissue allograft - Leptomeningeal metastases - Untreated CNS metastases - Serious or uncontrolled medical disorders Other protocol-defined inclusion/exclusion criteria apply

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Have questions? Live support is available 24/7 - Call 855-907-3286 or email clinical.trials@bms.com

Have questions? Live support is available 24/7 -
Call 855-907-3286 or email clinical.trials@bms.com