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BMS Recruiting Study icon

Recruiting

Trial ID CA055-001  |   NCT05209295

A Study to Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignancies

Summary

  • Phase 1
  • Male and Female Gender icon
  • 18+
    Age Range
  • 18
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to evaluate the effect of moderate or severe liver impairment on the drug levels of oral azacitidine and the safety and tolerability of oral azacitidine in participants with myeloid malignancies.

Nearest Recruiting Site

Key Eligibility Criteria

Inclusion Criteria: - Documented diagnosis of Myelodysplastic syndrome, Acute myeloid leukemia, Non-acute promyelocytic leukemia, Chronic myelomonocytic leukemia, Philadelphia-negative myeloproliferative neoplasms, Myelodysplastic syndrome Myeloproliferative neoplasms overlap, Accelerated phase and blast phase Myeloproliferative neoplasms, Blastic plasmacytoid dendritic cell neoplasm according to the World Health Organization (WHO) 2016 classification - Life expectancy of ≥ 3 months - Stable renal function without dialysis for at least 2 months prior to investigational product administration - Has moderate or severe hepatic impairment as defined by National Cancer Institute Organ Dysfunction Working Group criteria Exclusion Criteria: - Chemotherapy or radiotherapy within 2 weeks or 5 half-lives, whichever is longer, prior to the first day of investigational product administration - Persistent, clinically significant non-hematologic toxicities from prior therapies which have not recovered to < Grade 2 - Any condition including the presence of laboratory abnormalities, which places the participant at unacceptable risk if he/she were to participate in the study - History of inflammatory bowel disease, celiac disease, prior gastrectomy, gastric bypass, upper bowel removal, or any other gastrointestinal disorder or defect that would interfere with the absorption of the investigational product and/or predispose the participant to an increased risk of gastrointestinal toxicity Other protocol-defined inclusion/exclusion criteria apply

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Group 1

ASSIGNED INTERVENTION
  • Drug: Onureg

Study Arms

Experimental: Group 2

ASSIGNED INTERVENTION
  • Drug: Onureg

Study Arms

Other: Group 3

ASSIGNED INTERVENTION
  • Drug: Onureg
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