Inclusion Criteria:
Participants must satisfy the following criteria to be enrolled in the study:
1. Participant (male or female) is ≥ 18 years of age at the time of signing the informed
consent form (ICF).
2. Participant must understand and voluntarily sign an ICF prior to any study-related
assessments/procedures being conducted.
3. Participant is willing and able to adhere to the study visit schedule and other
protocol requirements.
4. Participant must have a history of NHL that has relapsed or progressed.
5. Participant has an ECOG PS of 0 or 1.
6. Participants must have acceptable laboratory values as specified in the protocol.
Exclusion Criteria:
1. Participant has cancer with symptomatic central nervous system (CNS) involvement
2. Participant is on chronic systemic immunosuppressive therapy or corticosteroids or
subjects with clinically significant graft-versus-host disease (GVHD). Intranasal,
inhaled, topical, or local corticosteroid injections, or steroids as premedication for
hypersensitivity reactions are exceptions to this criterion.
3. Inadequate cardiac function or significant cardiovascular disease
4. Participant has received prior investigational therapy directed at CD47 or SIRPα.
5. Participant had major surgery ≤ 2 weeks prior to starting CC-96673.
6. Participant is a pregnant or lactating female or intends to become pregnant during
participation of the study.
7. Participant has known active human immunodeficiency virus (HIV) infection.
8. Participant has active hepatitis B or C (HBV/HCV) infection.
9. Ongoing treatment with chronic, therapeutic dosing of anti-coagulants.
10. History of autoimmune hemolytic anemia or autoimmune thrombocytopenia.
11. History of concurrent second cancers requiring active, ongoing systemic treatment.
12. Participant has any significant medical condition, laboratory abnormality, or
psychiatric illness that would prevent the subject from participating in the study.
13. Participant has active, uncontrolled, or suspected infection. Other protocol defined
inclusion/exclusion criteria could apply.
Active, Not Recruiting
