Key Inclusion Criteria:
- At least 18 years old at screening and body weight > 45 kg at screening
- Diagnosed with oHCM consistent with current ACCF/AHA 2011 and meet their
recommendations for invasive therapies
- Referred or under active consideration within the past 12 months for SRT procedure and
willing to have SRT procedure
- Has documented left ventricular ejection fraction (LVEF) ≥ 60% at Screening
- Has documented oxygen saturation at rest ≥ 90% at Screening
Key Exclusion Criteria:
- Persistent or permanent atrial fibrillation and subject not on anticoagulation for ≥ 4
weeks prior to screening and/or not adequately rate controlled ≤ 6 months prior to
screening
- Previously treated with invasive septal reduction (surgical myectomy or percutaneous
alcohol septal ablation [ASA])
- For individuals on beta blockers, calcium channel blockers, or disopyramide, any dose
adjustment of these medications < 14 days prior to screening or an anticipated change
in regimen during the first 16 weeks of the study
- Any medical condition that precludes upright exercise stress testing
- Paroxysmal, intermittent atrial fibrillation with atrial fibrillation present at
screening
- Prior treatment with cardiotoxic agents, such as doxorubicin or similar
- Has a history or evidence of any other clinically significant disorder, condition, or
disease that would pose a risk to subject safety or interfere with the study
evaluation, procedures, or completion
Active, Not Recruiting
