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Trial ID CC-92480-MM-002  |   NCT03989414

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)

Celgene Corporation, a wholly owned subsidiary of Bristol-Myers Squibb Company

Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • 26
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to evaluate the safety and preliminary efficacy of CC-92480 in combination with standard treatments.

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Key Eligibility Criteria

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2 For participants in Cohorts A, B, C, D, E, F, H, I, J, and K the following inclusions will also apply: - Documented diagnosis of multiple myeloma (MM) and measurable disease - Documented disease progression during or after their last antimyeloma regimen - Achieved a response (minimal response [MR] or better) to at least 1 prior treatment regimen Exclusion Criteria: - Plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or clinically significant amyloidosis - Known central nervous system (CNS) involvement with myeloma - Received immunosuppressive medication within the last 14 days of initiating study treatment - Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment Other protocol-defined inclusion/exclusion criteria apply

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Cohort A: CC-92480 with bortezomib and dexamethasone

ASSIGNED INTERVENTION
  • Drug: CC-92480, Bortezomib, Dexamethasone

Study Arms

Experimental: Cohort C: CC-92480 with carfilzomib and dexamethasone

ASSIGNED INTERVENTION
  • Drug: CC-92480, Dexamethasone, Carfilzomib

Study Arms

Experimental: Cohort D: CC-92480 with bortezomib and dexamethasone

ASSIGNED INTERVENTION
  • Drug: CC-92480, Bortezomib, Dexamethasone

Study Arms

Experimental: Cohort F: CC-92480 with carfilzomib and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Carfilzomib, CC-92480, Dexamethasone

Study Arms

Experimental: Cohort G: CC-92480 with bortezomib and dexamethasone

ASSIGNED INTERVENTION
  • Drug: CC-92480, Dexamethasone, Bortezomib

Study Arms

Experimental: Cohort H: CC-92480 with elotuzumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Dexamethasone, CC-92480, Elotuzumab

Study Arms

Experimental: Cohort I: CC-92480 with isatuximab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Dexamethasone, Isatuximab, CC-92480

Study Arms

Experimental: Cohort J: CC-92480 with elotuzumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Elotuzumab, Dexamethasone, CC-92480

Study Arms

Experimental: Cohort K: CC-92480 with isatuximab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Dexamethasone, CC-92480, Isatuximab

Study Arms

Experimental: Subcohort B1: CC-92480 with daratumumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Dexamethasone, CC-92480, Daratumumab

Study Arms

Experimental: Subcohort B2: CC-92480 with daratumumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Daratumumab, CC-92480, Dexamethasone

Study Arms

Experimental: Subcohort B3: CC-92480 with daratumumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Dexamethasone, CC-92480, Daratumumab

Study Arms

Experimental: Subcohort E1: CC-92480 with daratumumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: CC-92480, Daratumumab, Dexamethasone

Study Arms

Experimental: Subcohort E2: CC-92480 with daratumumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Daratumumab, Dexamethasone, CC-92480

Study Arms

Experimental: Subcohort E3: CC-92480 with daratumumab and dexamethasone

ASSIGNED INTERVENTION
  • Drug: Dexamethasone, CC-92480, Daratumumab
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