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Trial ID CC-93269-MM-001  |   NCT03486067

Study of CC-93269, a BCMA x CD3 T Cell Engaging Antibody, in Participants With Relapsed and Refractory Multiple Myeloma

Celgene Corporation, a wholly owned subsidiary of Bristol-Myers Squibb Company

Summary

  • Phase 1
  • Male and Female Gender icon
  • 18+
    Age Range
  • 25
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

Study CC-93269-MM-001 is an open-label, Phase 1, dose escalation (Part A and C) and expansion (Parts B and D), first-in-human clinical study of CC-93269 in subjects with relapsed and refractory multiple myeloma.

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Key Eligibility Criteria

Inclusion Criteria: - History of multiple myeloma with relapsed and refractory disease - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Must have measurable disease as determined by the central laboratory Exclusion Criteria: - Symptomatic central nervous system involvement of multiple myeloma - Prior autologous stem cell transplant ≤ 3 months prior - Prior allogeneic stem cell transplant with either standard or reduced intensity conditioning ≤ 12 months prior - History of concurrent second cancers requiring active, ongoing systemic treatment Other protocol-defined inclusion/exclusion criteria apply

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Administration of CC-93269

ASSIGNED INTERVENTION
  • Drug: CC-93269
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