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Active, Not Recruiting

An Investigational Immuno-Therapy Study of Experimental Medication BMS-986242 Given in Combination With Nivolumab in Patients With Advanced Cancer - CA024-001

Updated: 05 July, 2018   |   ClinicalTrials.gov

CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the trial guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 4

    Location(s)

  • Active, Not Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Dose Escalation
Drug: BMS-986242 Biological: Nivolumab
Experimental: Dose Expansion
Drug: BMS-986242 Biological: Nivolumab

Key Eligibility Criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Histologic or cytological confirmation of a malignancy that is advanced (metastatic and/or unresectable) with measureable disease per RECIST v1.1 - Participants must have received and then progressed or been intolerant to at least 1 standard treatment regimen in the advanced or metastatic setting if such a therapy exists - Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 - Ability to swallow tablets - Adequate bone marrow and organ function, as defined by the protocol Exclusion Criteria: - Participants with known or suspected CNS metastases, untreated CNS metastases, or with the CNS as the only site of disease (patients with controlled brain metastasis allowed to enroll) - Ocular melanoma - Any significant acute or chronic medical illness - Prior malignancy - Other active malignancy requiring concurrent intervention - Prior organ allograft or allogeneic bone marrow transplantation - Participants with active, known, or suspected autoimmune disease - Requirement for daily supplemental oxygen - Uncontrolled or significant cardiovascular disease - Pre-existing liver disease - Gastrointestinal disease known to interfere with absorption Other protocol defined inclusion/exclusion criteria could apply

Have questions? Call 855-907-3286 or Email Us

Have questions?
Call 855-907-3286 or Email Us